... It has been known since the 1930s that the use of the above female hormones suppresses ovulation, but at the time they had to be injected in large doses and had strong side effects, so they were not put to practical use as contraceptives. However, in the late 1950s, it became possible to synthesize effective steroid hormones that could be taken orally, and they were first researched and developed in 1959 by American G. Pincus and others. This coincided with a time when the need for contraception was increasing, such as to curb population growth, and so they quickly spread around the world. ... *Some of the terminology that mentions "Pincus, G." is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
… 上記の女性ホルモンを使用すると排卵が抑制されることは,1930年代からわかっていたが,当時は多量に注射しなければならず,副作用も強いために,避妊薬としては実用化しなかった。しかし,50年代の後半に,口から飲んで有効なステロイドホルモンが合成されるようになったため,アメリカのピンカスG.Pincusらによって59年に初めて研究開発された。当時は人口増加抑制など,避妊の必要性が高まった時期と一致したため急速に世界中に普及した。… ※「Pincus,G.」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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