...Subsequently, with the progress of electron microscopy and the physicochemical study of biomembranes, it gradually became clear that a unit membrane in which proteins are bound to the phospholipids in the middle layer on both sides could not explain the structure of actual biomembranes. Singer SJ Singer and Nicolson GL Nicolson (1972) proposed the fluid mosaic model, which states that it is more appropriate to think of biomembranes as a mosaic system of liquid and solid phases rather than as a solid phase (Figure). The two back-to-back layers of phospholipids and the various proteins incorporated into these lipid portions are arranged in a mosaic pattern, and it is thought that the membrane itself is fluid and that only non-covalent bonds exist between the molecules so that the constituent molecules can diffuse and move within the membrane. ... *Some of the terminology that refers to "fluid mosaic model" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…その後,電子顕微鏡法の検討が進み,また生体膜の物理化学的研究から,中層のリン脂質にタンパク質が両側から挟む形で結合するような単位膜は,実際の生体膜の構造を説明できないことがしだいに明らかになった。 生体膜を固相と見るのではなく,液相―固相のモザイク系と考えたほうがより妥当だとする流動モザイクモデルfluid mosaic modelがシンガーS.J.SingerとニコルソンG.L.Nicolson(1972)によって提唱された(図)。背中合せ2層のリン脂質とこの脂質部分に組み入れられた各種タンパク質はモザイク的配列をとっており,また膜自体が流動的で構成分子は膜内部を拡散し移動できるように,分子間に非共有結合だけが働いていると考える。… ※「fluid mosaic model」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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