Eosinophile chemotactic factor

Japanese: eosinophile chemotactic factor(英語表記)eosinophilechemotacticfactor
Eosinophile chemotactic factor

…Of these antibodies, the immunoglobulin IgE antibody (also called reagin) has tissue adhesion and adheres to the surface of mast cells present in connective tissue. When a pathogenic antigen invades the mast cells again, an antigen-antibody reaction occurs on the surface of the mast cells, causing the granules contained in the mast cells to degranulate, releasing chemical mediators such as histamine, SRS-A (slow reactive substance of anaphylaxis), and ECF (eosinophile chemotactic factor) contained in the granules to the outside of the cells. These chemical mediators then cause reactions such as increased vascular permeability, smooth muscle contraction, increased glandular secretion, and eosinophil migration, which is thought to result in allergic diseases. …

*Some of the terminology that refers to "eosinophile chemotactic factor" is listed below.

Source | Heibonsha World Encyclopedia 2nd Edition | Information

Japanese:

…これらの抗体のうち,免疫グロブリンであるIg E抗体(レアギンreaginともいう)は組織固着性があり,結合組織中に存在するマスト細胞の表面に固着する。そこに病因となる抗原が再び侵入してくると抗原抗体反応がマスト細胞の表面で起こり,その結果,マスト細胞に含まれている顆粒が脱顆粒現象を起こし,顆粒の中に含まれているヒスタミン,SRS‐A(slow reactive substance of anaphylaxis),ECF(eosinophile chemotactic factor)などの化学伝達物質を細胞外に遊離する。すると,これらの化学伝達物質の作用によって,血管の透過性の亢進,平滑筋の収縮,腺分泌の亢進,好酸球の遊走などの反応が起こり,その結果,アレルギー疾患が起こると考えられている。…

※「eosinophile chemotactic factor」について言及している用語解説の一部を掲載しています。

出典|株式会社平凡社世界大百科事典 第2版について | 情報

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