…Very low density lipoproteins (VLDL) are lipoproteins synthesized in the liver that transport endogenous triglycerides to peripheral tissues and then become cholesterol-rich low density lipoproteins (LDL). LDL is particularly important as a lipoprotein that transports and supplies cholesterol to peripheral tissues and regulates the de novo synthesis of cholesterol in each tissue. High density lipoproteins (HDL) are synthesized in the liver and are rich in phospholipids and cholesterol. One of their roles is thought to be to transport cholesterol from peripheral tissues to the liver. … *Some terminology explanations that mention "de novo synthesis" are listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…超低比重リポタンパク質(VLDL)は肝臓で合成されたリポタンパク質で,内因性のトリグリセリドを末梢組織に運搬した後,コレステロールに富んだ低比重リポタンパク質(LDL)になる。このLDLは末梢組織にコレステロールを運搬・供給し,各組織でのコレステロールのデノボ合成de novo synthesis(代謝過程の中間産物を回収・再利用するような合成のしかたではなく,簡単な前駆物質から新たにある構造体が合成されること)を調節するリポタンパク質としてとくに重要である。高比重リポタンパク質(HDL)は肝臓で合成され,リン脂質とコレステロールに富んでおり,その役割の一つとしてコレステロールを末梢組織から肝臓に運搬する機能が考えられている。… ※「de novo synthesis」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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