…Pyrazinamide (abbreviated as PZA) is highly regarded in the West and is used for the first two months of short-term chemotherapy, but it is not widely used in Japan due to its strong side effects. The main side effects are hearing loss caused by mycin-based drugs, balance disorders caused by streptomycin sulfate, liver damage caused by TH, PZA, and RFP, vision problems caused by EB, mental disorders caused by cycloserine (abbreviated as CS) and TH, peripheral neuritis caused by INH and EB, gastrointestinal disorders caused by TH and PAS, and allergic reactions to various drugs. These side effects must be discovered early through regular examinations and requests from the patient, and measures must be taken, such as stopping the medication and switching to another drug or carrying out desensitization therapy. … *Some of the terminology that mentions "cycloserine" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…ピラジナミドpyrazinamide(PZAと略記)は欧米では高く評価され,短期化学療法の当初2ヵ月くらい用いられているが,副作用が強く日本では多くは使われていない。 副作用のおもなものは,マイシン系薬剤による聴力障害,硫酸ストレプトマイシンによる平衡障害,TH・PZA・RFPの肝臓障害,EBの視力障害,サイクロセリンcycloserine(CSと略記)・THの精神障害,INH・EBの末梢神経炎,TH・パスによる胃腸障害,各種薬剤に対するアレルギー反応などである。これらの副作用については,定期的検査と患者からの申出によって早期に発見し,服薬を中止して他剤に変更したり,減感作療法を行うなどの対策を講じなければならない。… ※「cycloserine」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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