…The word originates from the Greek word atopos (strange), meaning strange disease. In 1923, Arthur F. Coca proposed the term as a disease concept that encompasses a group of allergic diseases with a strong hereditary tendency, centered on hay fever (hay fever) and bronchial asthma. In 1925, Coca himself revealed that antibody-like substances, which can be verified by skin reactions, are present at a high rate in the serum of patients with atopic dermatitis, and Coca named this substance atopic reagin. … From [Bronchial Asthma]…Once it was discovered that the true nature of allergies is a hypersensitivity phenomenon based on antigen-antibody reactions, research into antigens and antibodies in bronchial asthma was actively pursued, building on previous research into hay fever. Arthur F. Coca (1875-1959) called the specific antibodies found in asthma patients reagins (1923). Forty years later, Kosei Ishizaka made the groundbreaking discovery that reagin antibodies were IgE (a type of immunoglobulin) (1966), ushering in a new era in asthma research. … *Some of the terminology used to refer to "Coca, AF" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…語源はギリシア語のatopos(奇妙な)で,奇妙な病気strange diseaseの意味。1923年コカArthur F.Cocaが,枯草熱(花粉症),気管支喘息(ぜんそく)を中心とする遺伝傾向が強い一群のアレルギー性疾患を包括する疾患概念として提唱したものである。25年にはコカ自身によって,アトピー罹患患者の血清中に,皮膚反応によって証明される抗体様物質が高率に存在することが明らかにされ,コカはこの物質をアトピー性レアギンatopic reaginと名づけた。… 【気管支喘息】より…アレルギーの本態が抗原抗体反応に基づく過敏現象であることが解明されるや,それまで行われていた枯草熱の研究などをふまえて,気管支喘息における抗原,あるいは抗体の研究が精力的に進められていった。コカArthur F.Coca(1875‐1959)は喘息患者に認められる特異な抗体をレアギンと呼んだ(1923)。以後40年を経て,石坂公成によりレアギン抗体がIgE(免疫グロブリンの一つ)であるという画期的な発見がなされ(1966),喘息研究は新しい時代を迎えた。… ※「Coca,A.F.」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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