…In 1883, E. Kraepelin of Germany came up with the idea of using drugs to induce psychosis, and nine years later published a paper observing the psychological effects of drugs. After that, research on mescaline and other subjects followed, but in 1943 LSD, which induces psychosis in minute amounts of (50/1 million) grams, was discovered, and in 1952 the antipsychotic drugs reserpine and chlorpromazine were discovered. When Brodie and others proposed the hypothesis that the main source of these effects was serotonin in the brain, psychopharmacology as a science was established. Psychotropic drugs [Kobayashi Tsukasa]. … *Some of the terminology that mentions "Brodie, BB" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…ドイツのE.クレペリンは1883年に薬で精神病を起こそうと考え,9年後に薬物の心理的影響を観察した論文を発表した。その後,メスカリンの研究などが続いたが,1943年に(50/100万)gという微量で精神異常を誘発するLSDが,また52年に抗精神病薬であるレセルピンとクロルプロマジンが発見され,これらの作用の本体は脳内セロトニンであるという仮説がブロディB.B.Brodieらによって提案されたときに,科学としての精神薬理学が確立されたとみるべきである。向精神薬【小林 司】。… ※「Brodie,B.B.」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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