C 37 H 67 NO 13 (733.93). A 14-membered ring macrolide antibiotic produced by Streptomyces erythreus . The hydrate is a white crystal. Melting point 135-140 °C. After solidification, remelting point 190-193 °C. -78° (ethanol). Easily soluble in ethanol and acetone, insoluble in water. Exhibits antibacterial activity against gram-positive bacteria, gram-negative bacteria, mycoplasma, chlamydia, etc. Acts on the 50S subunit of the ribosome to inhibit protein synthesis. Used orally and topically. LD 50 2580 mg/kg (mouse, oral). [CAS 114-07-8] Source: Morikita Publishing "Chemical Dictionary (2nd Edition)" Information about the Chemical Dictionary 2nd Edition |
C37H67NO13(733.93).Streptomyces erythreusが産生する十四員環マクロライド抗生物質.水和物は白色の結晶.融点135~140 ℃.固化後,再融点190~193 ℃.-78°(エタノール).エタノール,アセトンに易溶,水に不溶.グラム陽性菌,グラム陰性菌,マイコプラズマ,クラミジアなどに抗菌力を示す.リボソームの50Sサブユニットに作用してタンパク質合成を阻害する.経口や外用薬で用いる.LD50 2580 mg/kg(マウス,経口).[CAS 114-07-8] 出典 森北出版「化学辞典(第2版)」化学辞典 第2版について 情報 |
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