Alcoholic fatty liver disease

Japanese: アルコール性脂肪肝 - あるこーるせいしぼうかん
Alcoholic fatty liver disease

…In chronic hepatitis, the liver usually swells and hardens by one to two fingers. In alcoholic fatty liver and alcoholic cirrhosis, the liver is usually enlarged, but it quickly returns to normal size with abstinence from alcohol. In severe decompensated cirrhosis accompanied by jaundice and ascites, the liver becomes impalpable, and the degree of liver atrophy roughly parallels the severity of the liver disease. …

From [Fatty Liver]

…Normally, a fatty liver is one in which more than 50% of the observable cells are affected by this type of degeneration, but in severe cases, it can affect almost all cells. Causes include obesity (overnutrition), diabetes, excessive alcohol consumption (known as alcoholic fatty liver), and drug toxicity, but it can also be caused by severe nutritional disorders (protein deficiency, malabsorption). In other words, excessive fat intake, increased production of fatty acids in liver cells, impaired fatty acid oxidation, and impaired production and secretion of lipoproteins are all related to the development of fatty liver. …

*Some of the terminology that refers to "alcoholic fatty liver" is listed below.

Source | Heibonsha World Encyclopedia 2nd Edition | Information

Japanese:

…慢性肝炎では,肝臓は通常1~2横指,腫大して硬くなる。アルコール性脂肪肝とアルコール性肝硬変では,ほとんど肝腫大を伴うが,禁酒によって急速に正常の大きさに戻る。黄疸,腹水を伴う重症な非代償性肝硬変では,肝臓が触れられなくなり,肝臓の萎縮の程度は肝臓疾患の重症度にほぼ並行する。…

【脂肪肝】より

…通常,観察しうる細胞の50%以上にこのような変性をみとめるものを脂肪肝と呼ぶが,ひどい場合には,ほとんど全細胞に及ぶ。原因としては,肥満(栄養過多),糖尿病,飲酒過剰(これをアルコール性脂肪肝という),薬物毒性などがあるが,一方,高度の栄養障害(タンパク質欠乏,吸収不良)によっても生じる。すなわち,脂肪摂取過剰,肝細胞内での脂肪酸の産生亢進,脂肪酸酸化障害,リポタンパク質の産生,分泌の障害などが脂肪肝の発生に関連している。…

※「アルコール性脂肪肝」について言及している用語解説の一部を掲載しています。

出典|株式会社平凡社世界大百科事典 第2版について | 情報

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