…The mechanism of the reaction that converts the energy of oxidation-reduction into the energy of ATP synthesis has long been a mystery. However, in 1966, P. Mitchell proposed the chemiosmotic hypothesis, which is based on two points: (1) H + is transported unidirectionally from one side of the membrane to the other as the respiratory chain electron transport reaction proceeds, and (2) the resulting uneven distribution of H + becomes the energy source for ATP synthesis (see figure). After about 10 years of debate, this original theory was accepted, and Mitchell received the Nobel Prize in Chemistry in 1978. … *Some of the terminology that mentions "Mitchell, P." is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…酸化還元のエネルギーをATP合成のエネルギーに変換する反応の機構は長い間のなぞであった。しかし1966年ミッチェルP.Mitchellは,(1)呼吸鎖電子伝達反応が進行する際に,H+が膜を横切って一方から他方へ定方向的に輸送され,(2)その結果として生じるH+の偏在がATP合成のエネルギー源となる,という2点を骨子とする化学浸透圧説chemiosmotic hypothesisを提唱した(図参照)。約10年に及ぶ論争を経てこの独創的な学説は承認され,ミッチェルは78年度のノーベル化学賞を受けた。… ※「Mitchell,P.」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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