...Because the symptoms of muscarine poisoning are very similar to the effects of stimulating the vagus nerve, the hypothesis was put forward that the vagus nerve releases a muscarinic-like substance from its terminal to transmit excitement to the effector organs it controls, but it was later clarified that the transmitter substance is acetylcholine. Reflecting this history, even today, the site on which acetylcholine acts in organs controlled by the parasympathetic nerves (acetylcholine receptors) is called a muscarinic receptor, to distinguish it from the acetylcholine receptors on muscle cells and autonomic ganglion cells controlled by motor nerves. Alkaloids [Yutaka Kasuya]. ... *Some of the terminology that mentions "muscarinic receptor" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…ムスカリン中毒の症状が,迷走神経を刺激したときの効果と非常によく似ているところから,迷走神経はその終末からムスカリン類似物質を放出して,支配する効果器に興奮を伝達しているのではないかとの仮説が出されたこともあるが,その後,伝達物質の本体はアセチルコリンであることが明確になった。このような経緯を反映して,現在でも副交感神経の支配を受けている器官に存在するアセチルコリンが働きかける場所(アセチルコリン受容体)を,ムスカリン様受容体muscarinic receptorと呼んで,運動神経の支配下にある筋肉細胞上や自律神経節細胞上のアセチルコリン受容体と区別している。アルカロイド【粕谷 豊】。… ※「muscarinic receptor」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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