…(3) Several viruses with strong affinity for myelin-forming or myelin-retaining cells are known in animals, but their presence in humans has only been confirmed in the case of progressive multifocal leukoencephalopathy. The papovavirus that causes this disease selectively attacks oligodendroglia, which are myelin-retaining cells in the central nervous system, resulting in the formation of demyelinating lesions. (4) Multiple sclerosis, the most important demyelinating disease of the central nervous system in humans, is a disease of unknown cause, and both the possibility of an autoimmune mechanism and the possibility of an infectious disease selectively affecting myelin-retaining cells are considered. … *Some of the terminology that mentions "papovavirus" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…(3)髄鞘形成または保持細胞に親和性の強いウイルスは,動物ではいくつかのものが知られているが,ヒトで確認されているのは進行性多巣性白質脳症の場合のみである。この疾患の原因となるパポバウイルスpapovavirusは中枢の髄鞘保持細胞であるオリゴデンドログリアoligodendrogliaを選択的に侵すため,脱髄性の病変が形成される。(4)ヒトにおける中枢神経系の脱髄疾患中最も重要なものである多発性硬化症はまだ原因不明の疾患であり,自己免疫機転による可能性と,髄鞘保持細胞に選択的な感染症である可能性の両方が考えられている。… ※「papovavirus」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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