…This phenomenon is now called Koch's phenomenon, because the body's reaction differs between primary infection and reinfection, with reinfection showing a stronger resistance. In 1902, while studying sea anemone toxins, Charles R. Richet (1850-1935) and Paul Portier (1866-1962) of France discovered that dogs could be injected with a small amount of toxin at first without dying, but that the dogs became so sensitive to the toxin that even a very small amount of toxin injected thereafter would cause severe symptoms such as difficulty breathing, diarrhea, and bloody stool, and they would die. They called this anaphylaxis (ana means opposite, no, and phylaxis means defense or protection, and is a Latin word referring to a state of no defense). … *Some of the terminology that mentions "Portier, P." is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…これは現在コッホ現象と呼ばれているが,初感染の場合と再感染の場合とでは生体の反応が異なり,再感染では抵抗がたかまった反応を示すためである。1902年,フランスのリシェCharles R.Richet(1850‐1935)とポルティエPaul Portier(1866‐1962)は,イソギンチャクの毒素の研究をしているうちに,初めに少量の毒素をイヌに注射しても死なないが,その結果イヌは毒素に対して非常に過敏になり,その後はごくわずかな量の毒素を注射しても,呼吸困難,下痢,下血などの激しい症状を起こして死亡することを見いだした。そして,これをアナフィラキシーanaphylaxis(anaは反対,無,phylaxisは防御,保護の意で,無防御の状態を指すラテン語)と呼んだ。… ※「Portier,P.」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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