…However, it has been discovered that some bacteria and viruses can react directly with complement even without antibodies. These bacteria and viruses first react with serum protein components different from C1, C4, and C2, namely factor B, factor D, properdin, and C3, and then react with C3 (again), C5, C6, C7, C8, and C9. In this case, factor D acts like C1, factor B acts like C2, and the first C3 acts like C4, and properdin acts to enhance these reactions. … *Some of the terminology explanations that mention "properdin" are listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…ところが,細菌やウイルスの一部には,抗体がなくても直接補体と反応できるものがあることがわかってきた。これらの細菌やウイルスは,C1,C4,C2とは異なる血清中のタンパク質成分,つまりB因子,D因子,プロペルジンproperdinおよびC3とまず反応し,そのあとでC3(再び),C5,C6,C7,C8,C9と反応していく。このとき,D因子はC1のような,B因子はC2のような,初めのC3はC4のような働きをし,プロペルジンはそれらの反応を増進させるように作用する。… ※「properdin」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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