Setlow, RB (English spelling) SetlowRB

Japanese: Setlow,R.B.(英語表記)SetlowRB
Setlow, RB (English spelling) SetlowRB

…In insects, the life span varies depending on whether they survive the winter as an egg, pupa, or adult. RW Art and RB Setlow extracted cells from the skin of seven mammalian species with different life spans at relatively similar ages in their life spans, cultured them, irradiated them with ultraviolet light to damage the DNA, and compared their ability to repair the damage. They found that the cells of animals with longer life spans had a stronger ability to repair damaged DNA, and they believed that longevity is linked to the repair mechanism of genetic material. Indeed, the existence of a genetic background to life span can be seen in the life spans of parents and children, the life spans of twins, the life spans of men and women, and the life spans of patients with genetic premature aging and other genetic diseases. …

*Some of the terminology explanations that mention "Setlow, RB" are listed below.

Source | Heibonsha World Encyclopedia 2nd Edition | Information

Japanese:

…昆虫類では,冬を卵,さなぎ,成虫のどの段階で越すかによって,生存期間が異なってくる。ハートR.W.HartとセットローR.B.Setlowとは寿命の異なる7種類の哺乳類の皮膚から,それぞれの寿命の相対的に同じ年齢に相当する時点に細胞を取り出して培養し,これに紫外線を照射してDNAに傷をつくり,その傷の修復能力を比較した結果,寿命の長い動物の細胞ほど傷ついたDNAの修復能力が強いことを示し,寿命の長さと遺伝物質の修復機構が結びついていると考えた。確かに,寿命に遺伝的な背景が存在することは,親子の寿命,双生児の寿命,男女(雌雄)の寿命,遺伝的早老病患者や他の遺伝病患者の寿命などからもうかがうことができる。…

※「Setlow,R.B.」について言及している用語解説の一部を掲載しています。

出典|株式会社平凡社世界大百科事典 第2版について | 情報

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