…Most of these actions are exerted by the Fc portion of the antibody. The main actions are the promotion of phagocytosis by binding to phagocytes such as neutrophil polymorphonuclear leukocytes and macrophages (opsonization), the induction of cytotoxicity by stimulating macrophages (antibody-dependent cellular cytotoxicity, ADCC), the release of inflammatory substances by stimulating mast cells and basophilic leukocytes, and the activation of the complement system. For an antibody to exert these actions, it must first bind to an antigen. … *Some of the terminology that mentions "opsonization" is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…その作用のほとんどは抗体部分のFc部分によって現される。そのおもなものは,好中性多核白血球,マクロファージ(大食細胞)などの食細胞への結合による食作用の促進(オプソニン作用),マクロファージの刺激による細胞障害作用の誘発(抗体依存性細胞障害作用,ADCC),肥満細胞や好塩基性白血球の刺激による炎症作用物質の放出,補体系の活性化などである。 抗体が以上のような作用を現すには,抗体がまず抗原と結合することが必要である。… ※「オプソニン作用」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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