Isonicotinic Acid Hydrazide - Isonicotinic Acid Hydrazide

4-pyridinecarboxylic acid hydrazide. C ₆ H ₇ N ₃ O(137.14). Abbreviated as INAH. Also known as isoniazid. It is obtained from isonicotinic acid or its ester and hydrazine. Colorless or white crystals. Melting point 170-173 °C. Slightly bitter. Easily soluble in water, 10% soluble in boiling ethanol. Insoluble in other organic solvents. Changes with light. Aqueous solution is relatively stable. It is used as an antituberculous drug, and its growth inhibitory effect on tuberculosis bacteria is stronger than that of streptomycin and para-aminosalicylic acid. Side effects include tremors in the hands and feet, insomnia, dry mouth, dizziness, and constipation. _{LD 50} 150 mg/kg (mouse, intravenous injection). [CAS 54-85-3]

Source: Morikita Publishing "Chemical Dictionary (2nd Edition)" Information about the Chemical Dictionary 2nd Edition

4-pyridinecarboxylic acid hydrazide．C₆H₇N₃O(137.14)．略称INAH．イソニアジドともいう．イソニコチン酸またはそのエステルとヒドラジンから得られる．無色または白色の結晶．融点170～173 ℃．わずかに苦い．水に易溶，沸騰エタノールに約10％ 溶ける．ほかの有機溶媒に不溶．光によって変化する．水溶液は比較的安定である．抗結核薬として用いられ，結核菌発育阻止作用はストレプトマイシン，パラアミノサリチル酸よりも強く，副作用として手足のふるえ，不眠症，口渇，めまい，便秘などがある．LD₅₀ 150 mg/kg(マウス，静注)．[CAS 54-85-3]

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