...A disease in which abnormalities in the production and excretion of uric acid lead to hyperuricemia, causing repeated bouts of pain in peripheral joints. There are primary or idiopathic gout and secondary or secondary gout, but gout generally refers to primary or idiopathic gout. The underlying cause is unknown, with congenital or genetic predispositions. Secondary or secondary gout is caused by hematopoietic diseases, drug poisoning, and enzyme deficiencies. For this reason, gout is considered a syndrome. The underlying cause in both cases is hyperuricemia due to excessive intake of purines such as animal protein, and excessive production of uric acid and reduced excretion by the kidneys. ... *Some of the terminology explanations that mention "primary gout" are listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
…尿酸の生成や排出の異常から,高尿酸血症となり,末梢の関節などに発作的な疼痛を繰り返す病気。一次性または特発性痛風と二次性または続発性痛風があるが,一般に痛風といえば一次性または特発性痛風のことをいう。背景には先天性あるいは遺伝性素因があり,原因は不明である。二次性または続発性痛風は,造血器疾患,薬剤中毒,酵素欠損によって起こる。そのため痛風は一つの症候群とされている。 いずれも基盤となるのは,動物性タンパク質のようなプリン体摂取過剰,尿酸の過剰生成と腎臓での排出低下による高尿酸血症である。… ※「一次性痛風」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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