progeria

Japanese: progeria
progeria

...However, individuals that have completed their role in producing the next generation become harmful to the younger individuals of the next generation as competitors for limited food resources, and so the parent generation is eliminated when the guarantee mechanism is released or aging genes are expressed. Evidence supporting this theory includes the fact that the lifespan of an organism is specific to each species, that some organisms have lethal genes, that certain genetic diseases appear at specific ages, that people become more susceptible to cancer and various diseases as they age, and that the lifespan of cultured cells from patients with genetic premature aging (progeria and Werner syndrome) is shorter than that of normal individuals, and it is said that genes contain factors that determine aging and lifespan, or at least have a very large influence on it. (2) Error theory The idea that aging and lifespan are not determined genetically, but that the process of storing, transmitting, and expressing information in self-replication (replication), which is important for maintaining life, becomes damaged over time, causing errors and disorder, which is the cause of aging. ...

*Some of the terminology that mentions "progeria" is listed below.

Source | Heibonsha World Encyclopedia 2nd Edition | Information

Japanese:

…ところが,次の世代をこしらえて役目を終えた個体は,次代の若い個体にとっては限られた食物資源の競合者として,かえって有害な存在となるので,保証機構が解除されるか老化遺伝子が発現することによって,親世代の排除が行われるというのである。この説を支持する証拠として,生物の限界寿命はそれぞれの種に特有であること,ある種の生物では致死遺伝子の存在が指摘されていること,ある種の遺伝病が特定の年齢に発現すること,年をとると癌や種々の病気にかかりやすくなること,また遺伝的早老症(プロジェリアprogeria,ウェルナー症候群Werner syndrome)患者の培養細胞の寿命が正常者のものより短いことなどが挙げられ,遺伝子の中に老化や寿命を決めるか,少なくともひじょうに大きな影響をもつ因子が含まれているとする。(2)エラー説 老化や寿命は遺伝的に決められているのではなく,生命の維持に重要な自己増殖(複製)における情報の貯蔵・伝達・発現の過程が,時間がたつにしたがって損傷を受け,まちがいを生じて,秩序が乱れてくることが老化の原因になっているという考え方。…

※「progeria」について言及している用語解説の一部を掲載しています。

出典|株式会社平凡社世界大百科事典 第2版について | 情報

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