… When considering the question of how a base sequence can determine an amino acid sequence, one of the mysteries is that there are only four types of bases, but 20 types of amino acids. In 1961, FHC Crick and S. Brenner reported through brilliant genetic experiments and theoretical considerations that codons are made up of triplet bases, and that of the total 64 types of codons (4 x 4 x 4), 61 correspond to amino acids and three correspond to end-of-reading signals. In the same year, MW Nirenberg performed the first experiment to determine which codons correspond to which amino acids. … *Some of the terminology that mentions "Brenner, S." is listed below. Source | Heibonsha World Encyclopedia 2nd Edition | Information |
… 塩基配列がいかにしてアミノ酸配列を決定しうるのかという問題を考えるとき,その不思議さの一つは,塩基はたった4種類であり,アミノ酸は20種類もあることであった。1961年,クリックF.H.C.CrickとブレンナーS.Brennerは卓抜な遺伝的実験と理論的考察から,コドンは三つ組塩基より成立し,全部で64種(4×4×4)のコドンのうち,61種がアミノ酸に対応し,3種は読み終りの信号に対応すると報告した。同年,ニーレンバーグM.W.Nirenbergは,どのコドンがどのアミノ酸に対応するかを決定する実験を初めて行った。… ※「Brenner,S.」について言及している用語解説の一部を掲載しています。 出典|株式会社平凡社世界大百科事典 第2版について | 情報 |
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