Nucleophilic elimination reaction

Japanese: 求核脱離反応 - きゅうかくだつりはんのう（英語表記）nucleophilic elimination reaction

Also known as E reaction. When a strong base is applied to an alkyl halide, dehydrohalogenation occurs, resulting in the introduction of a double bond. It is thought that the nucleophilic reagent ^OH- acts on the hydrogen atom of the carbon atom adjacent to the carbon atom bonded to the halogen, resulting in the introduction of a double bond at the same time as the halogen atom is removed. This usually occurs when the reaction temperature is high. Steric hindrance is large, and in many cases the hydrogen atom attached to the carbon atom with fewer hydrogen atoms is removed.

Source: Encyclopaedia Britannica Concise Encyclopedia About Encyclopaedia Britannica Concise Encyclopedia Information

Japanese:

E反応ともいう。ハロゲン化アルキルに強塩基を作用させた場合に脱ハロゲン化水素が起り，二重結合が導入される反応。求核試薬である OH^- がハロゲンと結合している炭素原子の隣接炭素原子の水素原子に作用してハロゲン原子の脱離と同時に二重結合の導入が起るものと考えられる。普通は反応温度の高いときに起る。立体障害が大きく，水素原子の少いほうの炭素原子に結合した水素原子が脱離する場合が多い。

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